Effects of Inhaled Albuterol and Ipratropium Bromide
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چکیده
Study objective: Systemic administration of P-agonist and anticholinergic drugs markedly impair normal autonomic heart rate control. The purpose of this study was to quantify and compare the effects of therapeutic doses of inhaled albuterol and ipratropium on autonomic control of the cardiovascular system. Design: Randomized, double-blind, placebo-controlled, crossover design study. Setting: Tertiary-care hospital. Subjects: Twelve healthy male volunteers. Interventions: Subjects self-administered four puffs through a spacer device from one of three identical inhalers containing albuterol (100 |xg per puff), ipratropium (20 [ig per puff), or placebo in three different testing sessions. Measurements: ECG and noninvasive continuous BP traces were recorded at baseline and from
منابع مشابه
COMPARISON OF THE ACUTE BRONCHO DILATING EFFECTS OF INHALED IPRATROPIUM BROMIDE AND SALBUTAMOL IN PATIENTS WI TH CHRONIC OBSTRUCTIVE PULMONARY DISE ASE
Forty-five patients with chronic obstructive pulmonary disease were studied to compare the acute effects of ipratropium bromide (60 µg), salbutamol (300 µg) and placebo (3 puffs) on the forced expiratory volume in 1 sec (FEV 1) and forced vital capacity (PVC). Ipratropium bromide produced a significantly greater improvement than salbutamol in both FEV1 and FVC at 15,60 and 180 minutes afte...
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